ICR 12000 Ion Channel Reader

Based upon the versatility, precision, and sensitivity of atomic absorption spectroscopy (AAS) and Aurora Biomed’s patented microsampling process, the ICR 12000 is suitable for both ligand-gated and voltage-gated ion channels using cell-based flux assays. The ICR 12000 was designed for ultra high throughput ion channel screening of compound libraries against ion channel targets. Based on the robustness of Aurora Biomed’s ICR technology, the reader offers high sensitivity generating accurate drug rank order matching electrophysiology data. This new member of the ICR ion channel screening series provides the throughput to access compound QT liability early in the drug discovery process.
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Specifications

  • Medium Throughput: Up to 5000 wells/day
  • Single Channel: Measures 1 sample at a time
  • Minimum sample volume: 50 µl
  • Accommodation: 96/384-well microplates
  • Footprint: H.67 cm X W.55 cm X D.37 cm
  • Fuel Source: Acetylene / Compressed Air
  • Options: Plate Stacker / Bar Code Reader
  • Sensitivity: 0.05 ppm detection limit
  • Precision: < 5% CV


Applications

ICR technology is suitable for many types of ion channels broad applications include:

  • Shaker (Kv1.1, Kv1.4 and Kv1.5)
  • hERG
  • KCNQ4
  • B/SKCa
  • KCNB/TASK-3
  • Kir2.1
  • nAChR
  • KATP (P2X family)


 

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