离子通道技术
ICR 8000 离子通道阅读器
ICR 8000-离子通道技术，通过原子吸收光谱和通量检测来测定离子通道的活动，对于进行离子通道筛选是非常有用的。当前的应用包括更快更精确地评价hERG 钾通道相比于其他中高通量的离子通道筛选系统。与hERG通道的相互作用会导致QT间期延长综合征，监管机构因此需要对药品-QT的反应作用进行评估。
ICR 8000 具有广泛的应用，它可以用于测试电压门控 (hERG, BK/SK, Kv1.1, 1.4, 1.5, KCNQ, 2P等） 和配体门控 (KATP，nAChR 等) 离子通道。这让研究人员能加快与离子通道相关的疾病治疗与预防方面的药物开发。
设备优势 |
- programmable and automated
- Automatic dilution, calibration and cleaning
- Adaptable to existing robotic automation
- Sample dilution not required
- High sensitivity
- On-line dilution
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设备特征 |
- Medium Throughput: Up to 5000 wells/day
- Single Channel: Measures 1 sample at a time
- Minimum sample volume: 50 µl
- Accommodation: 96/384-well microplates
- Footprint: H.67 cm X W.55 cm X D.37 cm
- Fuel Source: Acetylene / Compressed Air
- Options: Plate Stacker / Bar Code Reader
- Sensitivity: 0.05 ppm detection limit
- Precision: < 5% CV
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其他特征 |
- Quenching effects associated with fluorescence
- Health hazards associated with radioisotopes
- Radioisotope disposal
- Work restrictions posed by Rb's short half-life
- Ideal for hERG channel assays
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Strategies for the real-time detection of Ca2+ channel events of single cells: recent advances and new possibilities
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