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重金属测定

Heavy Metal Determination

应用–USP重金属–I类

Application – USP Heavy Metals – Class I

传统的USP-231比色法测定重金属需要沉淀不溶性金属硫化物,然后目测这些沉淀的颜色。不幸的是,这种技术已被证明是非特异性,不敏感和劳动密集型。由于这些限制,USP对USP<231>提出了许多修订(USP-232、USP-233和USP-2232)。这些修订要求使用现代分析仪器来定量测量样品中的元素水平。

拟议的美国药典重金属指南指示哪些元素应该被检测到,在什么浓度水平。在USP<232>中,元素分为两类。第一类由剧毒元素砷(As)、镉(Cd)、铅(Pb)和汞(Hg)组成。药品中I类元素的检测是强制性的。USP现在建议首先在微波消解炉中消解样品,然后通过ICP-OES和/或ICP-MS测量感兴趣的元素。电感耦合等离子体(ICP)光谱仪提供多种分析物的精密测试。但是与其他现代分析仪器相比,ICP光谱仪相对昂贵。

Aurora的LUMINA 3300原子荧光光谱仪利用蒸汽氢化物发生器将分析物从样品基质中分离出来,大大减少了样品介质的干扰,从而提高了灵敏度。表1中总结的性能数据表明,LUMINA 3300的灵敏度与ICP-OES或ICP-MS获得的数据相当或更高,而LUMINA平台的成本只是ICP系统成本的一小部分。

总之,LUMINA 3300提供了一种高精度、经济高效的重金属测定溶液,用于测定痕量金属。LUMINA 3300为氢化物形成元素的检测提供了无与伦比的灵敏度,是需要分析仪器测试I类重金属的研究人员的理想解决方案。原子荧光光谱法比传统的质谱技术更灵敏、更可靠,是一种理想的解决方案,已被证明能满足USP<232>、USP<233>和USP<2232>中提出的新的USP要求。

The classic colorimetric USP-231 method for heavy metal determination requires the precipitation of insoluble metal sulfides, followed by visual determination of the color of these resulting precipitations. Unfortunately this technique has been shown to be non-specific, insensitive and labour intensive. Due to these limitations, the USP has proposed a number of revisions to USP <231> (USP-232, USP-233 and USP-2232). These revisions require the use of modern analytical instruments to quantitatively measure the elements levels in the samples.

The proposed USP heavy metal guidelines instruct which element should be detected and at what concentration level. In USP <232> elements are divided into 2 classes. Class I consists of the highly toxic elements Arsenic (As), Cadmium (Cd), Lead (Pb) and Mercury (Hg). Testing for class I elements in pharmaceutical products is mandatory. The USP now recommends that samples first be digested in a microwave digestion oven and then the elements of interest measured by ICP-OES and/or ICP-MS. Inductively coupled plasma (ICP) spectrometers offer precision testing for multiple analytes. Unfortunately, ICP spectrometers are relatively expensive when compared against other modern analytical instruments.

Aurora’s LUMINA 3300 atomic fluorescence spectrometer utilizes a vapour hydride generator to separate analytes from the sample matrix, greatly reducing the interference from the sample media and thereby increasing the sensitivity. Performance data summarized in Table 1 shows that the sensitivity of the LUMINA 3300 is comparable or superior to data obtained from ICP-OES or ICP-MS, while the cost of the LUMINA platform is a fraction of the cost of an ICP system.

In summary, the LUMINA 3300 provides a highly precise, cost effective heavy metal determination solution for the determination of sub-trace levels of metals. The LUMINA 3300 offers unbeatable sensitivity for the detection of hydride forming elements and is an ideal solution for researchers requiring an analytical instrument to test for Class I heavy metals. Atomic fluorescence spectrometry is more sensitive and reliable than traditional mass spectrometry techniques and provides an ideal solution that has been proven to satisfy the new USP requirements laid out in USP <232>, USP <233> and USP <2232>.


LUMINA3300

LUMINA 3300 原子荧光光谱仪

下载应用报告


LUMINA 3300 性能数据

元素

检出限 (ppb)

Arsenic (As) 0.01
Cadmium (Cd) 0.001
Lead (Pb) 0.01
Mercury (Hg) 0.001