ICR 8100离子通道阅读器
ICR8100 利用原子吸收光谱仪和通量分析的离子通道技术，在离子通道筛选中起到十分重要的作用。相较于其他方法，我们能更快、更准确、更精确地评估hERG钾元素通道。hERG通道与心脏QT间期延长综合征相关。因此，对离子通道具有调节作用的化合物需要进行QT依赖性评估。
ICR 8100有广泛的运用。例如，评定电压门控离子通道（hERG, BK/SK, Kv1.1, 1.4, 1.5, KCNQ, 2P等）和配体门控离子通道（(KATP, nAChR等)，帮助研究人员加快药物（治疗和预防离子通道相关疾病）的开发的工作
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Applications
Publications
- • Nonradioactive Rubidium Efflux Assay Technology for Screening of Ion Channels（Georg C. Terstappen）
- • Ion Flux and Ligand Binding Assays for Analysis of Ion Channels（Georg C. Terstappen）
- • Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells
- • Screening technologies for ion channel drug discovery
- • Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel
- • High-throughput analysis of drug binding interactions for the human cardiac channel, Kv1.5
- • Cellular HTS Assays for Pharmacological Characterization of Na V 1.7 Modulators
- • Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants
- • Evaluation of the Rubidium Efflux Assay for Preclinical Identification of hERG Blockade
- • Characterization of a hERG Screen Using the IonWorks HT: Comparison to a hERG Rubidium Efflux Screen
- • Development of an HTS Assay for Na , K -ATPase Using Nonradioactive Rubidium Ion Uptake
- • Rb + Flux through hERG Channels Affects the Potency of Channel Blocking Drugs: Correlation with Data Obtained Using a High-Throughput Rb + Efflux Assay
- • Atomic Absorption Spectroscopy in Ion Channel Screening
- • Nonradioactive Rubidium Ion Efflux Assay and Its Applications in Drug Discovery and Development
- • Validation of an Atomic Absorption Rubidium Ion Efflux Assay for KCNQ/M-Channels Using the Ion Channel Reader 8000
- • High Throughput Assay Technologies for Ion Channel Drug Discovery
- • A High Throughput Screening Techno logy-Overcoming Bottlenecks in Ion Channel Drug Targets
- • A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux and atomic absorption spectrometry